Literature summary extracted from

Kuo, C.C.; Liu, J.F.; Chang, J.Y.
DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors (2006), J. Pharmacol. Exp. Ther., 316, 946-954.

Application

EC Number	Application	Comment	Organism
2.1.1.63	medicine	MGMT can modulate cytotoxicity of camptothecin-derived topoisomerase I inhibitors, MGMT overexpression reveals more resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea, camptothecin, 7-ethyl-10-hydrocamptothecin and topotecan, alteration of MGMT expression coincides with camptothecin-induced cell death and poly(ADP-ribose) polymerase cleavage	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.1.1.63	overexpression in CHO-derived Tet-on-inducible cells, knockdown of MGMT expression with small interfering RNA in HONE-1 cells	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.1.1.63	additional information	no differences in protein levels and catalytic activity of topoisomerase I between MGMT-proficient and MGMT-deficient cells from the Tet-On-inducible and small interfering RNA systems	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.63	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.63	HT-29 cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.63	O6-methylguanine DNA methyltransferase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)